Other ingredients: None. Capsule: hypromellose, sorbitol, silicon dioxide, water.
AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, soy, eggs, dairy, fish or shellfish.
Suggested Use
Take two capsules daily with/without food or as directed by a qualified health care practitioner.
Main Applications
* Blocks the production of allergic responses
* Relieves symptoms of allergy
Source
Multi-Sourced
Pregnancy / Nursing
None.
Cautions
None known.
Allergies- pain without gain
Allergies are a common problem that affects 20% of Americans, and the prevalence of allergy has lately been on the rise. Allergies are caused by a glitch in the immune system. In any normal immune system, plasma cells produce proteins called antibodies, which patrol the body like tiny police officers in search of proteins that are foreign to the body and signal the presence of a problematic invader. When antibodies find such an invader, they alert the immune cell authorities to trigger an immune response. The least common kind of antibody, immunoglobulin E (IgE), is normally present in very low amounts and is only used to set off an immune reaction in response to a parasitic infection. |
However, some people have hereditary predispositions to react to harmless compounds (allergens) such as food proteins, animal hair proteins, plant pollens, drugs, or substances like latex. IgE antibodies bind to immune cells called mast cells and basophils, which are concentrated in skin and mucous membrane surfaces. When the body is exposed to the allergen recognized by IgE, the antibody tells the cells to "degranulate", releasing all kinds of signaling mediators including histamine. These mediators immediately act on surrounding tissues to make blood vessels dilate and smooth muscle contract. Depending on where the allergen is found, this reaction will produce symptoms ranging from irritated sinuses to itchy skin to breathing difficulties.
Allergies can be combated by blocking the allergic response or by targeting inappropriate inflammation, which lies at the root of allergic symptoms. Aller-Control contains several natural compounds that work together to relieve the misery of allergies.
Perilla
Perilla frutescens is a plant whose leaves are commonly used as a garnish with raw fish in Japan. It is also used in Chinese herbal medicine. The functional components of perilla are flavonoid aglycones such as luteolin, apigenin, and rosmarinic acid, all of which have been studied for their anti-allergic and anti-inflammatory potential. One study assessed the clinical features of patients with asthma who had been given perilla seed oil for 4 weeks and found that breathing measurements were significantly increased compared to asthmatics who had not been treated.
Another study observed the effects of perilla seed extracts in volunteers with allergic symptoms such as sneezing, nasal obstruction, and itchy skin and eyes. 20 participants were given perilla seed extracts for 2-4 weeks, and their change in symptoms was evaluated. Symptoms were improved in all 20 patients, with significant improvements in sneezing (almost 40%), stuffed nose (over 60%) and itchy eyes (50%).
Luteolin
Luteolin is considered by many scientists to be the major active constituent in Perilla frutescens. Studies of this component have found that it exerts antimutagenic and anti-inflammatory-allergic effects. It is also recognized as an antioxidant scavenger of damaging free radicals, and as an inhibitor of protein kinase C, which is a key regulator in the initiation of inflammatory events such as smooth muscle constriction. In a mouse model that mimics some of the characteristic features of asthma, orally administered luteolin significantly decreased airway hyperactivity.
Rosmarinic acid
Rosmarinic acid is an extract that is found in plants such as rosemary and perilla. A randomized, double-blind, age-matched placebo-controlled parallel group study observed the effects of rosmarinic acid on 30 patients with seasonal allergic rhinoconjunctivitis (SAR). At the end of the trial period, there was a significant relief of itchy nose, watery eyes, itchy eyes and total symptoms. 55.6-70% of patients given rosmarinic acid reported global symptom relief, compared to only 30% of the placebo group.
Rosmarinic acid is well absorbed from the gastrointestinal tract and besides its effects on allergies, it has therapeutic potential in dealing with or preventing spasmogenic disorders, peptic ulcers, inflammatory diseases, liver toxicity, atherosclerosis, ischemic heart disease, and even cancer.
Quercetin
Quercetin is the most widely consumed flavonoid in the diet and has been used to treat a variety of complaints. Cellular and animal studies have found it to be a potent inhibitor of allergic and inflammatory responses. It is also a powerful antioxidant, and has benefits in heart health and diabetic complications. High intakes of quercetin are linked to lower mortality rates and heart attack incidence.
Mangiferin
Mangiferin is an extract of the plant Mangifera indica L. This plant is used in Cuba to help with various disorders including bronchial asthma, atopic dermatitis, and other allergic diseases. It has been reported to have antispasmodic, antimicrobial and fever-reducing effects. Mangiferin is the dominant component of this plant, and has strong anti-allergic effects. It also has antiviral, anti-tumour and antioxidant activity.
Butterbur
Butterbur (petasites hybridus) is a shrub found in Europe and in parts of Asia and North America. A study of patients with asthma or bronchitis found that butterbur improved lung ventilation and bronchial reactivity. Another study found that petasites had a comparable effect to the antihistamine cetirizine for seasonal allergic rhinitis, likely due to its effectiveness at reducing nasal responsiveness. It did not have the sedative effect associated with the drug.
Migraines are another disorder characterized by inappropriate inflammation, and in a double-blind placebo-controlled study, butterbur supplementation led to up to a 60% decrease in migraine frequency compared to the placebo group, and the migraine symptoms decreased in duration and intensity.
Cellular mechanisms
The ingredients in Aller-Control work at a number of levels to block allergic responses and alleviate the associated symptoms. Quercetin, mangiferin, and perilla and its extracts block the production of IgE, thereby inhibiting the allergic response from developing in the first place. Several of the compounds are able to stabilize mast cells to prevent them from degranulating and releasing histamine and other pro-inflammatory mediators. Perilla selectively blocks the activity of 5-lipooxygenase and quercetin blocks cyclooxygenases and lipooxygenases, which are enzymes that produce these mediators. Rosmarinic acid inhibits a key step of the complement system, which is an alternate pathway of inflammation. Luteolin, rosmarinic acid, quercetin and resveratrol are all effective at blocking the production of pro-inflammatory cytokines.
Some of the cytokines that are primarily responsible for allergic diseases include interleukin (IL)-4 and IL-5. IL-4 is one of the most important cytokines in the production of IgE and allergic inflammation. IL-5 is responsible for recruiting eosinophils, which are immune cells that assist in priming the immune system for an allergic response and are responsible for releasing pro-inflammatory mediators. Eosinophil accumulation is a distinctive feature of allergic inflammation. Luteolin, rosmarinic acid, quercetin and mangiferin are all able to block the production of IL-4 and IL-5, and the subsequent recruitment and activation of eosinophils.
For those who are sick of dealing with itching, sneezing, watery eyes, difficulty breathing, or even worse symptoms, the compounds of Aller-Control are brought together to provide a natural solution for allergies.
References
Ueda H, Yamazaki C and Yamazaki M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol Pharm. Bull. 2002;25(9):1197-1202.
Makino T, Furuta Y, Wakushima H, Fujii H, Saito K and Kano Y. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol. Pharm. Bull. 2001;24(10):1206-1209.
Makino T, Furuta Y, Wakushima H, Fujii H, Saito K and Kano Y. Anti-allergic effect of Perilla frutescens and its active constituents. Phytotherapy Research. 2004;17:240-243.
Okamoto M, Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y, Kataoka M, Niiya K, Harada M. Effects of perilla seed oil supplementation on leukotriene generation by leukocytes in patients with asthma associated with lipometabolism. Int Arch Allergy Immunol. 2000 Jun;122(2):137-42.
Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N and Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clinical and Experimental Allergy. 2000;30:501-508.
Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagisawa R, Inoue K-I, Sadakane K, Icinose T and Yoshikawa T. Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clin Exp Allergy. 2004;34:971-977.
Das M, Ram A and Ghosh B. Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice. Inflammation Research. 2003;52:101-106.
Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K-I, Yasuda A, Natsume M, Baba S, Ichiishi E-I and Yoshikawa T. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med. 2004;229:247-254.
Al-Sereitia MR, Abu-Amerb KM and Sena P. Pharmacology of rosemary (Rosemarinus officinalis Linn.) and its therapeutic potentials. Indian Journal of Experimental Biology. 1999;37:124-131.
Rivera DG, Balmaseda IH, Leon AA, Hernandez BC, Montiel LM, Garrido GG, Cuzzocrea S and Hernandez RD. Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin. Journal of Pharmacy and Pharmacology. 2006;58:385-392.
Garcia D, Delgado R, Ubeira FM, Leiro J. Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin. International Immunopharmacology. 2002;2:797-806.
Sa-Nunes A, Rogerio AP, Medeiros AI, Fabris VE, Andreu GP, Rivera DG, Delgado R and Faccioli LH. Modulation of eosinophil generation and migration by Mangifera indica L. extract (Vimang). International Immunopharmacology. 2006;6(9):1515-1523.
Baolin L, Inami Y, Tanaka H, Inagaki N, Tinuma M, Nagai H. Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro. Planta Med. 2004;70(4):305-309.
Danesch UC. Petasites hybridus (Butterbur root) extract in the treatment of asthma- an open trial. Altern Med Rev. 2004;9(1):54-62.
Lee DKC, Carstairs IJ, Haggart K, Jackson CM, Currie GP and Lipworth BJ. Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy. 2003;33:882-886. |
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