Take 1 tablet daily with a meal, or as directed by your qualified health consultant. Easy-Solv™ tablets disintegrate within several minutes of ingestion.
Keep out of the reach of children.
Easy-Solv tablets dissolve within minutes of ingestion.
Methylation
Methylation is the process by which methyl groups attach to different substances in the body, working either to protect them or transform them. For instance, when properly attached the DNA, methyl groups can act in a protective capacity, keeping inappropriate genes (e.g. oncogenes) from being expressed. Methylation is a naturally occurring process, which decreases as we age. Recent research indicates that, not unlike oxidation, poor methylation is directly related to many diseases, including cancer, heart disease, liver disease, and neurological disorders.
Methionine is an essential amino acid found in many foods. During normal metabolism, methionine is partially converted to homocysteine, a toxic amino acid. However, in the presence of an adequate methylation system, homocysteine is quickly converted back to methionine. Homocysteine is kept in check via the following process:
(1) Methylation back to methionine and SAMet;
(2) Transsulfuration-conversion to sulphur amino acids (e.g. to cysteine and thence to glutathione (GSH)); and,
(3) Homocysteine export to plasma.
The battle against cardiovascular disease has been largely unsuccessful because the focus has been cholesterol alone. This failure shouldn’t be too much of a surprise, because large-scale human studies show that dietary cholesterol and blood cholesterol are mostly unrelated, and that feeding animals normal diets with the addition of high amounts of cholesterol does not cause arteriosclerosis. Over 50% of heart attacks are not associated with high cholesterol.
A well-formulated homocysteine PF product consists of nutrients and vitamins with the proven ability to successfully reduce homocysteine levels.
A well-formulated homocysteine PF product is formulated with methyl group donors and supporting nutrients to facilitate methylation. Methylation is inhibited by poor dietary habits (excessive protein and fat or inadequate nutrient content), alcohol, smoking, and genetic predisposition. Impairment of methylation results in elevated levels of homocysteine, a toxic amino acid and a serious health risk. Homocysteine is reduced to methionine, a biologically useful amino acid, by enzymes that require folic acid, B12, B6, and methyl groups. Intristic factor facilitates the absorption of B12.
References
i. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, Palma-Reis RJ, Boers GH, Sheahan RG, Israelsson B, Uiterwaal CS, Meleady R, McMaster D, Verhoef P, Witteman J, Rubba P, Bellet H, Wautrecht JC, de Valk HW, Sales Luis AC, Parrot-Rouland FM, Tan KS, Higgins I, Garcon D, Andria G, et al. (1997). “Plasma homocysteine as a risk factor for vascular disease.” J Am Med Assoc; 277: 1775-1781.
ii. McCully KS. (1996), “Homocysteine and vascular disease.” Nature Medicine 2(4): 386-9.
iii. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, Tishler PV, Hennekens CH. (1992), “ A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.” JAMA 268(7): 877-81.
iv. Cooney CA. (1993), “Are somatic cells inherently deficient in methyl metabolis? A proposed mechanism for DNA methylation loss, senescence, and aging.” Growth Dev Aging 57(4): 261-73.
v. Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PW, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH. (1995), “Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.” N Engl J Med 332(5): 286-91.
